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KMID : 0370220110550050374
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Yakhak Hoeji
2011 Volume.55 No. 5 p.374 ~ p.378
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Anti-platelet Aggregation Study of Fermented Galgeun Tang and Fermented Ssanghwa Tang
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Son Chu-Young
Song Byung-Jeong
Ma Jin-Yeul
Kwon Kwang-Il
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Abstract
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This study was performed to evaluate enhanced effect of fermented Galgeun tang (GGT) and Ssanghwa tang (SHT) on the anti-platelet aggregation. Platelet aggregation assay was performed In vitro using human platelet rich plasma(PRP) and In vivo using SD-rat plasma by platelet aggregometer. Pharmacodynamic parameters, and , were calculated using Winnolin. SD-rats administered 1 g/kg of oriental medicine every 12 hr for 8 days. Platelet aggregation was measured by optical method with collagen inducer (4 /ml). In In vitro anti-platelet study, of GGT-A was lower than that of GGT-con about 79.13 /ml. And of SHT-A and SHT-B was lower than that of SHT-con about 122.73 and 110.15 /ml, respectively. It is assumed that fermented GGT and SHT were more effective than original medicine. In multiple administration study, anti-platelet effect was significantly increased both GGT and SHT. Fermented GGT and SHT were more effective than original herbal medicine on anti-platelet aggregation.
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KEYWORD
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Galgeun tang, Ssanghwa tang, fermentation, anti-platelet, original medicine
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